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Topical tazarotene is classified as FDA pregnancy category X studies in animals or humans have demonstrated foetal abnormalities, while tretinoin and adapalene are pregnancy category C animal reproduction studies have shown an adverse effect on the foetus and there are no adequate and wellcontrolled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.

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This fundamental conflict between careful, slow scientific progress and the need to do something for patients who are suffering now and going to die soon is a theme Gladwell revisits in his article.

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